Early life elevations of methionine oxidation and ornithine track and predict cystic fibrosis structural lung disease
We identified BAL metabolites associated with SLD, MPO and NE, detectable in the earliest stages of CF. MetO, %OxMet, NAcMet and ornithine predicted bronchiectasis development, outperforming established biomarkers. These metabolites reflect oxidising, proteolytic and other enzymatic activities of neutrophils, highlighting potential therapeutic avenues.
Authors
- David Mager (ORCID: https://orcid.org/0000-0002-2760-2867)
- Lisa J. M. Slimmen
- Sarah Mansour
- Genoah L. Collins (ORCID: https://orcid.org/0000-0002-4863-7516)
- Joshua D. Chandler (ORCID: https://orcid.org/0000-0003-3211-7935)
- James T. Lyles (ORCID: https://orcid.org/0000-0003-3111-6527)
- G. Rosas da Silva
- Vincent D. Giacalone (ORCID: https://orcid.org/0000-0002-3496-7776)
- Silvia Estevão
- Rabindra Tirouvanziam (ORCID: https://orcid.org/0000-0003-3526-9985)
- Daan Caudri (ORCID: https://orcid.org/0000-0002-8191-8598)
- B. Manaï
- Camilla Margaroli (ORCID: https://orcid.org/0000-0003-3952-0778)
- Padma Rao
- Limin Peng
Institutions
- University of North Carolina at Chapel Hill (US)
- Royal Children's Hospital (AU)
- Emory University (US)
- The University of Melbourne (AU)
- Princess Margaret Hospital for Children (AU)
- Erasmus MC (NL)
- Lung Institute (US)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Children's Healthcare of Atlanta (US)
- Murdoch Children's Research Institute (AU)
- Perth Children's Hospital
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1183/23120541.00238-2025
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cystic Fibrosis Foundation
- American Society of Hematology
- Nederlandse Cystic Fibrosis Stichting
- National Health and Medical Research Council
- National Heart, Lung, and Blood Institute