Neurofibromatosis type I (NF1) and bone involvement in a pediatric setting: insights from FGF23 levels
In conclusion, this represents the first study assessing FGF23 levels in NF1 children and its possible relationship with decreased bone mineral density. Contrarily to previous observations, no significant differences were found between NF1 patients and controls regarding FGF23 and αKlotho levels. Additionally, there was no clear association between FGF23 and bone involvement, thus suggesting that this phenomenon is not FGF23-driven or FGF23 derangements might occur later in life. Further research is needed to understand the multifactorial mechanisms and determine optimal intervention strategies.
Authors
- Masami Ikehata (ORCID: https://orcid.org/0000-0001-9835-9991)
- Federico Giacchetti
- Claudia Giavoli (ORCID: https://orcid.org/0000-0002-6787-1543)
- Federico Grilli
- Eriselda Profka (ORCID: https://orcid.org/0000-0002-0001-1530)
- Valentina Collini
- Carlo Alfieri (ORCID: https://orcid.org/0000-0003-3860-5219)
- Valeria Citterio
- Federica Natacci (ORCID: https://orcid.org/0000-0002-8625-3089)
- Giulia Rodari (ORCID: https://orcid.org/0000-0002-2200-9538)
- Deborah Mattinzoli (ORCID: https://orcid.org/0000-0003-0478-022X)
- Claudia Cesaretti (ORCID: https://orcid.org/0000-0002-6819-0846)
- Alessandro Risio
- Giulietta Scuvera
- Giovanna Mantovani
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s13052-025-01941-9
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00