MicroRNA-4497 Is Downregulated in Pediatric Allergic Diseases and Suppresses Th2 Inflammation in an Animal Model

MiR-4497 expressions were consistently downregulated in pediatric subjects with AD, AR, and BA. Allergic inflammation was significantly reduced in human mast cell-1 transfected with miR-4497 and in the treated mouse model. Further research is needed to elucidate the epigenetic mechanisms by which miR-4497 modulates allergic diseases and to explore its potential as a noninvasive biomarker for diagnosis and treatment. .