Antibody signatures elicited by potent and subpotent whole-cell pertussis vaccines in mice
Whooping cough (pertussis) is a highly contagious respiratory disease caused by the Gram-negative bacterium, <i>Bordetella pertussis</i>. Globally, tens of millions of whole-cell pertussis (wP) vaccines are administered annually. Whole-cell pertussis vaccines are logistically complex to manufacture and get to market because of the need for each batch of vaccine to be evaluated in a highly laborious and challenging potency test known as the Kendrick assay, which involves mouse intracerebral challenges with <i>B. pertussis.</i> In this report, we describe efforts to develop a serology-based substitute for the Kendrick assay that relies on profiling antibody responses to wP vaccines.
Authors
- Prashant Kumar (ORCID: https://orcid.org/0000-0002-4959-3156)
- Jennifer Doering (ORCID: https://orcid.org/0000-0001-8749-774X)
- Kathryn Secrist
- David B. Volkin (ORCID: https://orcid.org/0000-0002-1448-1998)
- Jozelyn Pablo (ORCID: https://orcid.org/0000-0002-7286-7688)
- Andy Teng (ORCID: https://orcid.org/0000-0002-2088-2181)
- Yetunde Adewunmi (ORCID: https://orcid.org/0000-0001-6947-152X)
- Joseph J. Campo (ORCID: https://orcid.org/0000-0002-8652-0917)
- Nicholas John Mantis (ORCID: https://orcid.org/0000-0002-5083-8640)
- Vu Huynh
- Sangeeta B. Joshi
Institutions
- New York State Department of Health (US)
- Wadsworth Center (US)
- University of Kansas (US)
- Antigen Discovery (United States) (US)
- Pharmaceutical Formulations (United States) (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1128/spectrum.03253-24
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation