Prognostic Value of Systemic Immune Inflammation Index in Squamous Cell Lung Cancer

<b>Background/Objectives:</b> Squamous cell lung cancer (SCC) presents a significant treatment challenge due to its poor prognosis and limited therapeutic options. In many resource-limited countries, access to advanced molecular testing is often unavailable, making the identification of novel and reliable prognostic markers crucial for improving patient selection for systemic treatments. <b>Methods:</b> This single-center, retrospective study investigated the prognostic value of inflammatory biomarkers, including the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), in 134 patients diagnosed with SCC. Patients were stratified into groups based on optimal cut-off values determined by ROC analysis for each biomarker. <b>Results:</b> Elevated levels of the SII, NLR, and PLR were significantly associated with shorter overall survival in patients with SCC (all <i>p</i> < 0.05). <b>Conclusions:</b> These easily accessible and cost-effective laboratory parameters are particularly valuable in settings where molecular testing is not available, aiding in the identification of high-risk patients and optimizing treatment selection for chemotherapy.