Association of TRPV1 and the SIRT3/SOD2 Signaling Pathway in Mononuclear Cells and Astrocyte-Derived Extracellular Vesicles in Patients with Schizophrenia
TRPV1 expressions in PBMCs and ADEs were reduced and closely correlated, and TRPV1 levels were associated with psychiatric symptoms and cognitive function in patients with schizophrenia. It was indicated that TRPV1 could be a biomarker for schizophrenia and reflect the disease severity.
Authors
- Huan Huang (ORCID: https://orcid.org/0000-0003-2071-5954)
- Rui Xu (ORCID: https://orcid.org/0000-0002-6631-9386)
- Zhongchun Liu (ORCID: https://orcid.org/0000-0001-5410-0312)
- Fashuai Chen
- Shijing Wang (ORCID: https://orcid.org/0000-0003-2736-4077)
- Yuan Li (ORCID: https://orcid.org/0000-0001-9809-9894)
- Hao Liu (ORCID: https://orcid.org/0000-0003-1938-8925)
- Xiao‐Wei Wang (ORCID: https://orcid.org/0000-0002-7472-3944)
- Chang Shu (ORCID: https://orcid.org/0000-0003-0749-1650)
- Huiling Wang
- Gaohua Wang (ORCID: https://orcid.org/0000-0003-4716-112X)
- Ying Xiong (ORCID: https://orcid.org/0000-0003-0532-6328)
Institutions
- Wuhan University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Brain Sciences
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3390/brainsci15040339
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China