Predicting rheumatoid arthritis progression from seronegative undifferentiated arthritis using machine learning: a deep learning model trained on the KURAMA cohort and externally validated with the ANSWER cohort
The FNN model exhibited robust performance in predicting the progression of RA from seronegative UA and maintained substantial sensitivity in an independent validation cohort. This model using only clinical and laboratory parameters has potential for predicting RA progression in patients with seronegative UA.
Authors
- Yuki Etani (ORCID: https://orcid.org/0000-0001-5741-5969)
- Hideki Amuro (ORCID: https://orcid.org/0000-0002-7299-2884)
- Yasutaka Okita (ORCID: https://orcid.org/0000-0003-3620-8412)
- Hirohiko Kohjitani (ORCID: https://orcid.org/0000-0002-8281-8396)
- Motomu Hashimoto (ORCID: https://orcid.org/0000-0002-9241-060X)
- Kosaku Murakami (ORCID: https://orcid.org/0000-0001-5981-4648)
- Koichi Murata (ORCID: https://orcid.org/0000-0002-7896-3937)
- T. Okano (ORCID: https://orcid.org/0000-0002-0873-5728)
- Tadashi Okano (ORCID: https://orcid.org/0000-0002-8849-9824)
- Masao Tanaka (ORCID: https://orcid.org/0000-0002-8942-2933)
- Ryota Hara (ORCID: https://orcid.org/0000-0001-8000-3196)
- Wataru Yamamoto (ORCID: https://orcid.org/0000-0002-0810-4221)
- Yo Ueda (ORCID: https://orcid.org/0000-0001-6065-8486)
- Takayuki Fujii (ORCID: https://orcid.org/0000-0002-6556-1226)
- Naofumi Yoshida (ORCID: https://orcid.org/0000-0002-7015-377X)
- Ayaka Yoshikawa
- Koji Nagai (ORCID: https://orcid.org/0000-0002-3183-4193)
- Shuichi Matsuda (ORCID: https://orcid.org/0000-0003-0802-1255)
- Akira Onishi
- Akio Morinobu (ORCID: https://orcid.org/0000-0002-4672-638X)
Institutions
- Kansai Medical University (JP)
- Kyoto University (JP)
- Kurashiki Central Hospital (JP)
- Kobe University Hospital (JP)
- Kyoto University Hospital (JP)
- Osaka Metropolitan University (JP)
- Nara Medical University (JP)
- Kobe University (JP)
- Tokyo Metropolitan University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13075-025-03541-8
- Citations
- 6
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 10.01
Funders
- Eli Lilly and Company
- Sanofi
- AbbVie
- Asahi Kasei Pharma Corporation
- Eisai
- Teijin Pharma
- Ono Pharmaceutical
- Chugai Pharmaceutical
- Eli Lilly Japan
- Sanofi K.K.
- Japan Society for the Promotion of Science
- Daiichi Sankyo Company
- Daiichi Sankyo Europe