INGESTIBLE BIOIMPEDANCE SENSING DEVICE FOR MONITORING INTESTINAL MUCOSAL PERMEABILITY

We present and validate the first ingestible bioimpedance sensing device capable of assessing relative changes in intestinal tissue permeability.Previously, impedance sensing capsules have been demonstrated for identifying acid-induced mucosal damage in the esophagus [1].However, no work has yet explored the link between tissue impedance and intestinal permeability beyond the esophagus.Inflammatory processes in intestinal mucosa affect intestinal ion transport channels and tight junction integrity, resulting in altered tissue conductivity.Here, we compare our bioimpedance sensing platform with established tissue permeability measuring equipment (Ussing chamber) using ex vivo animal intestinal tissues.The developed device reported a decrease in bioimpedance of 42.60.3%,49.21.6%,59.91.6% in response to 1, 3, and 5mM concentrations of ethylenediaminetetraacetic acid (EDTA), respectively, confirming that the device is able to differentiate permeable and healthy tissue.