CXCL8 upregulation mediates inflammatory cell infiltration and accelerates abdominal aortic aneurysm progression
CXCL8 was upregulated in patients with AAA and induced inflammatory cell infiltration and cytokine secretion. CXCL8-induced NLRP3 inflammasome regulation triggered pyroptosis in vascular smooth muscle cells, exacerbating inflammation and tissue damage in the aortic wall. This degeneration of the aortic media accelerated AAA progression.
Authors
- Lixin Wang (ORCID: https://orcid.org/0000-0002-1379-3906)
- Weiguo Fu (ORCID: https://orcid.org/0000-0001-5025-8542)
- Guoqiang Huang (ORCID: https://orcid.org/0000-0003-3900-399X)
- Xinsheng Xie
- Weifeng Lu (ORCID: https://orcid.org/0000-0003-4156-5094)
- Yulong Huang (ORCID: https://orcid.org/0009-0001-9597-7302)
- Xiang Hong
Institutions
- Fudan University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Science Progress
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/00368504251328754
- Citations
- 5
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Natural Science Foundation of China