Acute-on-Chronic Pancreatitis in a Patient With Ehlers-Danlos Syndrome: A Rare Association

Ehlers-Danlos Syndrome (EDS) is a connective tissue disorder known for its vascular complications, but it is rarely associated with chronic pancreatitis (CP). We describe a 32-year-old female with EDS who presented with acute-on-chronic pancreatitis, following prior episodes of pancreatitis and pseudocyst formation two years prior. This patient's EDS may have predisposed her to recurrent pancreatic inflammation, highlighting the potential role of tissue fragility in pancreatitis susceptibility. This case suggests a need for increased awareness of EDS as a risk factor for pancreatitis and emphasizes the importance of lifestyle counseling to prevent triggers.