Metrics of Genomic Complexity in the Evolution of Bacterial Endosymbiosis

Endosymbiosis can be considered a regressive or degenerative evolutionary process characterized at the genomic level by genome erosion and degeneration due to high mutational pressure toward AT (adenine and thymine) bases. The genomic and biological complexity of endosymbionts must be lower than that of the free-living bacteria from which they evolved. In the present work, we contrasted whether two proposed metrics for measuring genomic complexity in both types of bacteria, <i>GS</i> and <i>BB</i>, reflect their complexity, expecting higher values in free-living bacteria than in endosymbionts. On the other hand, we endeavored to delve into the factors that contribute to the reduction in metric values in endosymbionts, as well as their eventual relationship with six genomic parameters associated with functionality. This study aimed to test the robustness of these proposed metrics in a well-known biological scenario, such as the endosymbiosis process.

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Journal
Biology
Published
2025-03-25
DOI
https://doi.org/10.3390/biology14040338
Primary Topic
Evolution and Genetic Dynamics
Type
article
Field-Weighted Citation Impact
0.00

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article

Metrics of Genomic Complexity in the Evolution of Bacterial Endosymbiosis

Andrés Moyá, José Luis Tejera Oliver, Vicente Arnau, Miguel Verdú et al.
Biology
Evolution and Genetic Dynamics
article

Metrics of Genomic Complexity in the Evolution of Bacterial Endosymbiosis

Andrés Moyá, José Luis Tejera Oliver, Vicente Arnau, Miguel Verdú, Moisès Bernabeu, Wladimiro Dı́az-Villanueva, Pablo Román-Escrivá, Eleonora Paganin
article en

Abstract

Endosymbiosis can be considered a regressive or degenerative evolutionary process characterized at the genomic level by genome erosion and degeneration due to high mutational pressure toward AT (adenine and thymine) bases. The genomic and biological complexity of endosymbionts must be lower than that of the free-living bacteria from which they evolved. In the present work, we contrasted whether two proposed metrics for measuring genomic complexity in both types of bacteria, <i>GS</i> and <i>BB</i>, reflect their complexity, expecting higher values in free-living bacteria than in endosymbionts. On the other hand, we endeavored to delve into the factors that contribute to the reduction in metric values in endosymbionts, as well as their eventual relationship with six genomic parameters associated with functionality. This study aimed to test the robustness of these proposed metrics in a well-known biological scenario, such as the endosymbiosis process.

BiologyVol. 14(4)
Consejo Superior de Investigaciones Científicas (ES), Universitat de València (ES), Universidad de Granada (ES), Barcelona Supercomputing Center (ES), Generalitat Valenciana (ES), Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES), Centre d'Investigacions sobre Desertificació (ES), Centre for Biomedical Network Research on Rare Diseases (ES), Institute for Integrative Systems Biology (ES), Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES), Universitat Politècnica de Catalunya (ES)
Generalitat Valenciana, Ministerio de Ciencia e Innovación
Life in Land
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Evolution and Genetic Dynamics
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