Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis
Our vaccine candidate may interact with TLR2 and TLR4 and exhibit good immunogenicity, favoring Leishmania clearance. Our strategy provides a novel multi-epitope vaccine candidate and references for other vaccine developments.
Authors
- Tianhang Lv
- Yangjian Chi
- Xiaohui Fan (ORCID: https://orcid.org/0000-0002-6336-3007)
- Yu LingQi
- Shuoyan Tan (ORCID: https://orcid.org/0009-0008-0720-7625)
- Jianping Chen (ORCID: https://orcid.org/0000-0002-1186-7633)
- Xiaoyan Lu (ORCID: https://orcid.org/0000-0003-2534-8575)
- Jianhui Zhang (ORCID: https://orcid.org/0000-0002-6362-4027)
Institutions
- West China Medical Center of Sichuan University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s13071-025-06756-5
- Citations
- 4
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities