Affective bias predicts changes in depression during deep brain stimulation therapy
Our findings demonstrate that the affective bias task leverages the inherent negative interpretation bias seen in individuals with depression, providing a standardized measure of how these biases change over time. Unlike traditional mood assessments, which rely on subjective introspection, the affective bias task consistently measures changes in mood, offering potential as a tool to monitor mood changes and evaluate the candidacy of DBS treatment in refractory depression.
Authors
- Allison M. Waters (ORCID: https://orcid.org/0000-0003-2453-793X)
- Nader Pouratian (ORCID: https://orcid.org/0000-0002-0426-3241)
- Camille M. Steger
- Christopher J. Rozell (ORCID: https://orcid.org/0000-0001-5173-1661)
- Raissa Mathura (ORCID: https://orcid.org/0000-0002-2817-2133)
- Wayne K. Goodman (ORCID: https://orcid.org/0000-0001-6717-082X)
- John F. Magnotti (ORCID: https://orcid.org/0000-0003-2093-0603)
- Andrea Crowell (ORCID: https://orcid.org/0000-0002-9304-5763)
- Lydia Denison
- Brian Cui
- Helen S. Mayberg (ORCID: https://orcid.org/0000-0002-1672-2716)
- Christopher K. Kovach (ORCID: https://orcid.org/0000-0002-0117-151X)
- Kelly R. Bijanki (ORCID: https://orcid.org/0000-0003-1624-8767)
- Jess G. Fiedorowicz (ORCID: https://orcid.org/0000-0003-2057-4071)
- Vineet Tiruvadi (ORCID: https://orcid.org/0000-0001-5071-7091)
- Bailey Pascuzzi (ORCID: https://orcid.org/0009-0003-4188-8843)
- Ashan Veerakumar (ORCID: https://orcid.org/0000-0001-6544-1673)
- Prathik Kalva (ORCID: https://orcid.org/0000-0002-0869-4073)
- Brian Metzger (ORCID: https://orcid.org/0000-0002-4256-0108)
- Madaline Mocchi (ORCID: https://orcid.org/0000-0001-9893-2348)
- Kourtney Kanja
- Patricio Riva Posse
- Yvonne Y. Reed (ORCID: https://orcid.org/0009-0000-6547-1565)
Institutions
- University of Iowa (US)
- Georgia Institute of Technology (US)
- Emory University (US)
- University of Ottawa (CA)
- Baylor College of Medicine (US)
- Ottawa Hospital (CA)
- Circuit Therapeutics (United States) (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Human Neuroscience
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fnhum.2025.1539857
- Citations
- 1
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Hope for Depression Research Foundation
- National Institutes of Health