Iridium-Catalyzed, Copper-Induced Reductive Cyclization of NO<sub>2</sub>-Pyrrolarenes with CO<sub>2</sub> as a Single-Carbon Source
A new catalytic conversion type of nitro substrate with CO<sub>2</sub> as a single-carbon source is presented, wherein a great collection of azaheterocycles is generated by a newly established iridium-catalyzed, copper-induced reductive system. This catalytic procedure handily employs poly(methylhydrosiloxane) (PMHS) as the reductant to simultaneously realize the dual reduction of the highest oxidation-state nitro and CO<sub>2</sub> units in one operation. Elaborate mechanistic studies illustrate the essential role of the iridium catalyst in reducing the NO<sub>2</sub> moiety as well as the double functions of the copper additive in the subsequent formylation and C-H cyclization steps.
Authors
- Qiang Yan (ORCID: https://orcid.org/0000-0002-5550-3612)
- Jiang Nan (ORCID: https://orcid.org/0000-0001-5570-6834)
- Lanxin Zhu (ORCID: https://orcid.org/0000-0002-2721-9673)
- Shilei Liu (ORCID: https://orcid.org/0000-0002-9053-8458)
- Rui Cao
Institutions
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1021/acs.orglett.5c00677
- Citations
- 1
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70