Preoperative ECOG performance status as a predictor of outcomes in upper tract urothelial cancer surgery
Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional status measure in oncology, yet its prognostic value in upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific survival (HR 2.02, p < 0.001), and disease-free survival (HR 1.50, p = 0.003) than those with ECOG-PS 0-1. They also had a higher risk of major perioperative complications (odds ratio 2.46, p < 0.001). These findings support ECOG-PS as a valuable preoperative risk stratification tool.
Authors
- Hsin‐Chih Yeh (ORCID: https://orcid.org/0000-0003-4113-629X)
- Chih‐Chin Yu (ORCID: https://orcid.org/0000-0002-1344-1505)
- See‐Tong Pang (ORCID: https://orcid.org/0000-0002-2064-0828)
- Yung‐Tai Chen (ORCID: https://orcid.org/0000-0002-1194-4117)
- Yuan‐Hong Jiang (ORCID: https://orcid.org/0000-0002-7870-1574)
- Wun‐Rong Lin
- Chia‐Cheng Yu (ORCID: https://orcid.org/0000-0002-2620-1914)
- Ting-En Tai (ORCID: https://orcid.org/0000-0002-9869-1131)
- Ian-Seng Cheong
- Hsiang‐Ying Lee (ORCID: https://orcid.org/0000-0002-1503-5818)
- Wen‐Chi Chen (ORCID: https://orcid.org/0000-0002-6333-1638)
- Steven K. Huang (ORCID: https://orcid.org/0000-0001-8290-1037)
- Pi-Che Chen
- Jen‐Shu Tseng
- Hsu-Che Huang
- Chung-You Tsai
- Tsung-Mu Yang
- Wei‐Yu Lin (ORCID: https://orcid.org/0000-0002-9267-7988)
- Po‐Hung Lin (ORCID: https://orcid.org/0000-0002-7731-1443)
- I‐Hsuan Chen (ORCID: https://orcid.org/0000-0003-2720-7549)
- Chi‐Rei Yang
- Richard C. Wu (ORCID: https://orcid.org/0000-0001-9925-9677)
- Chia‐Chang Wu
- Zhihao Chen (ORCID: https://orcid.org/0000-0001-5317-6374)
- Yao-Chou Tsai
Institutions
- National Taiwan Normal University (TW)
- Chang Gung University of Science and Technology (TW)
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- China Medical University (TW)
- Tzu Chi University (TW)
- Taipei Medical University Hospital (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Mackay Memorial Hospital (TW)
- Mackay Medical University (TW)
- E-Da Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- Chia-Yi Christian Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Taiwan Adventist Hospital (TW)
- China Medical University Hospital (TW)
- Taipei Hospital (TW)
- National Taiwan University Hospital (TW)
- Chi Mei Medical Center (TW)
- Kaohsiung Veterans General Hospital (TW)
- Cardinal Tien Hospital (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
- Chang Jung Christian University (TW)
- I-Shou University (TW)
- Yuan Ze University (TW)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1038/s41598-025-95128-1
- Citations
- 2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Kaohsiung Municipal Ta-Tung Hospital
- Ministry of Science and Technology, Taiwan