Sexually dimorphic effects of angiopoietin-like 2 on energy metabolism and hypothalamic neuropeptide regulation
Angptl2 KD improved diet-induced obesity and associated metabolic dysfunction in male mice. The lack of similar changes in female mice and divergent MBH neuropeptide profile suggest that sex-dependent mechanisms underly the anabolic effects of this proinflammatory adipokine.
Authors
- P. P. Anthony (ORCID: https://orcid.org/0009-0008-1681-8583)
- Nathalie Thorin‐Trescases (ORCID: https://orcid.org/0000-0002-6398-1462)
- Cécile Hryhorczuk (ORCID: https://orcid.org/0000-0003-0101-292X)
- Romane Manceau
- Éric Thorin (ORCID: https://orcid.org/0000-0001-5827-8935)
- Stephanie Fulton (ORCID: https://orcid.org/0000-0001-7543-3546)
- Pauline Labbé (ORCID: https://orcid.org/0000-0002-1218-165X)
Institutions
- TransCanada (Canada) (CA)
- Montreal Heart Institute (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1038/s41366-025-01754-0
- Citations
- 1
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.39