Ginsenoside Rg5 modulates the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating inflammation, apoptosis and pyroptosis in hyperuricemia nephropathy
These results indicate that Rg5 can modulate the TLR4 and BCL-2 pathways by inhibiting NOX1, thereby alleviating oxidative stress, inflammation, pyroptosis, and apoptosis in HN, highlighting its potential as a therapeutic approach for controlling HN.
Authors
- Wenna Shi (ORCID: https://orcid.org/0000-0001-5611-0952)
- Yi-Ying Liu
- Hui Wan (ORCID: https://orcid.org/0000-0001-6227-710X)
- Jun-Ya Cheng
- Guan-Yue Shan
- Zi‐Jun Sun (ORCID: https://orcid.org/0009-0003-1116-9776)
- Haijun Li (ORCID: https://orcid.org/0000-0001-7165-1423)
- Yuxin Zhang (ORCID: https://orcid.org/0009-0004-6159-9309)
- Zhicheng Gao (ORCID: https://orcid.org/0000-0001-6488-8721)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1016/j.jgr.2025.03.009
- Citations
- 5
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 7.15