Slow-wave sleep is associated with nucleus accumbens volume in elderly adults
Slow-wave sleep (SWS) is essential for restorative neural processes and its decline is associated with both healthy and pathological ageing. Building on previous rodent research, this longitudinal study identified a significant association between nucleus accumbens (NAcc) volume and SWS duration in cognitively unimpaired older adults, whilst no significant link was observed between NAcc volume and N2 or rapid eye movement (REM) sleep percentage. Our findings support the involvement of the NAcc in ageing-related modulation of SWS and thus suggest the NAcc as a potential neural marker or therapeutic target for improving SWS.
Authors
- Péter Simor (ORCID: https://orcid.org/0000-0003-0695-166X)
- Petra Hermann (ORCID: https://orcid.org/0000-0002-9158-515X)
- Béla Weiss (ORCID: https://orcid.org/0000-0003-1031-0283)
- Tibor Kovács (ORCID: https://orcid.org/0000-0002-8603-8848)
- Vivien Tomacsek (ORCID: https://orcid.org/0000-0002-0524-7008)
- Éva M. Bankó (ORCID: https://orcid.org/0009-0001-5354-5077)
- Ádám Nárai (ORCID: https://orcid.org/0000-0001-5972-6509)
- Kazunobu Ban
- Noémi Báthori (ORCID: https://orcid.org/0000-0003-3971-4441)
- Adél Bihari (ORCID: https://orcid.org/0009-0008-0731-4711)
- Zoltán Vidnyánszky (ORCID: https://orcid.org/0000-0003-3914-3087)
Institutions
- Semmelweis University (HU)
- Eötvös Loránd University (HU)
- Budapest University of Technology and Economics (HU)
- University of Pecs (HU)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121173
- Citations
- 2
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Magyar Tudományos Akadémia
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal