The 133-kDa N-terminal region of myosin XVa is critical for normal structure and function of auditory and hair cells
Our findings confirm that <i>Myo15a</i> c.2455A > T spot knock-in mice replicate the abnormal hair cell morphology and dysfunction, as well as the hearing loss phenotype. Additionally, our results indicate that the novel c.2482C > T variant in the <i>MYO15A</i> gene can cause inner ear hair cell dysfunction and audiological disorders in this family.
Authors
- Jiong Dang
- Weiling Zhuo
- Yufen Guo (ORCID: https://orcid.org/0000-0002-4650-5237)
- Baicheng Xu (ORCID: https://orcid.org/0000-0002-9291-9369)
- Yong Li (ORCID: https://orcid.org/0000-0001-9939-094X)
- Yanli Wang (ORCID: https://orcid.org/0000-0002-7576-3235)
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Acta Oto-Laryngologica
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1080/00016489.2025.2479632
- Citations
- 1
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 1.46