Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson’s disease induced by 6-OHDA
This study performed 3D imaging of the composition and spatial arrangement of neuronal vascular units at both macroscopic and microscopic levels, laying the foundation for the creation of a whole-brain pathological map of PD. It also provides a basis for exploring unknown neural circuits and visualizing them.
Authors
- Yangyang Xu (ORCID: https://orcid.org/0000-0001-6427-7250)
- Yang Wu (ORCID: https://orcid.org/0000-0002-4354-8602)
- Yaping Wu (ORCID: https://orcid.org/0000-0001-9325-2212)
- Yi Shi (ORCID: https://orcid.org/0000-0003-2254-6541)
- Linglong Xiao
- Wei Wang (ORCID: https://orcid.org/0000-0002-3110-5767)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-3354-0690)
- Mengqi Wang (ORCID: https://orcid.org/0000-0003-3167-0464)
- Wei Pan (ORCID: https://orcid.org/0000-0002-8938-6880)
- Xiaojia Huang (ORCID: https://orcid.org/0000-0002-6075-1581)
- Lin Bai (ORCID: https://orcid.org/0009-0004-6370-3982)
Institutions
- Kunming University of Science and Technology (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- First People's Hospital of Yunnan Province (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fnagi.2025.1503168
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan Youth Science and Technology Foundation