Multigenetic pharmacogenomics–guided treatment shows greater improvements on motor symptoms compared to usual therapy in Parkinson’s disease: a small real-word prospective cohort study
MGPT demonstrates significant potential as a valuable tool for personalized treatment in PD patients. Additionally, we identified several SNPs associated with the responsiveness to chronic administration of multiple anti-parkinsonian drugs. However, to confirm these findings, well-designed studies with larger, well-characterized samples are necessary.
Authors
- Jiarui Yao
- Fengzhu Li (ORCID: https://orcid.org/0000-0001-6022-4055)
- Zhongbao Gao (ORCID: https://orcid.org/0000-0002-8890-7218)
- Siyu Chen (ORCID: https://orcid.org/0000-0002-6271-1858)
- Miao Wang (ORCID: https://orcid.org/0000-0001-7099-6809)
- Yifan Li (ORCID: https://orcid.org/0000-0002-3895-1974)
- Li Mao (ORCID: https://orcid.org/0000-0002-5383-379X)
- Xi Yin
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fphar.2025.1502379
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78