An Acetic Acid-Promoted Strecker Type Reaction of <i>N,N</i>-Disubstituted Aminomalononitriles: An Efficient Way for the Construction of α-Aminonitriles
A Strecker type reaction between aldehydes and readily available <i>N,N</i>-disubstituted aminomalononitriles has been realized for the first time to give an alternative strategy for the synthesis of α-aminonitriles. This reaction features broad substrate scope and the use of water as solvent, and its utility has been supported by the formal synthesis of racemic Clopidogrel and a 3-aminoindole type of compound.
Authors
- Shao‐Hua Wang (ORCID: https://orcid.org/0000-0002-4347-8245)
- Li Baiyang
- Yinliang Bai (ORCID: https://orcid.org/0000-0003-2766-9292)
- Wen Bao (ORCID: https://orcid.org/0000-0003-2295-3905)
- Yue Pu (ORCID: https://orcid.org/0000-0002-0156-2078)
- Bowen Wang (ORCID: https://orcid.org/0000-0003-3372-2678)
- Ye Zhang (ORCID: https://orcid.org/0000-0001-7433-1820)
- Runze Li (ORCID: https://orcid.org/0000-0002-6642-5904)
- Dao‐Yong Zhu (ORCID: https://orcid.org/0000-0001-7094-8700)
- Hai-Juan Jiao
Institutions
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1021/acs.joc.4c02945
- Citations
- 2
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Lanzhou Science and Technology Bureau
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Science and Technology Program of Gansu Province