Detection of Clinically Significant Drug-Drug Interactions in Fatal Torsades de Pointes: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System
Clinical evidence on DDIs is limited, and not all combinations of heart rate-corrected QT interval (QTc)-prolonging drugs result in TdP, even when involving high-risk drugs or those with known risk of TdP. This study provides a comprehensive real-world overview of drug-induced TdP, delimiting both clinically significant DDIs and negative DDIs, providing valuable insights into the safety profiles of various drugs, and informing the optimization of clinical practice.
Authors
- Ni Zhang (ORCID: https://orcid.org/0009-0005-3474-2269)
- Yuntao Jia (ORCID: https://orcid.org/0000-0001-8294-1012)
- Ya Yang (ORCID: https://orcid.org/0000-0002-7861-3793)
- Lin Song (ORCID: https://orcid.org/0000-0001-5425-3132)
- Huanhuan Ji (ORCID: https://orcid.org/0000-0002-0187-0038)
- Meiling Gong
- Li Gong (ORCID: https://orcid.org/0000-0002-8532-2206)
- Dongmei Deng
- Ri Zhou
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- China International Science and Technology Cooperation (CN)
- Daping Hospital (CN)
- Chongqing Cancer Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Medical Internet Research
- Published
- 2025-03-25
- DOI
- https://doi.org/10.2196/65872
- Citations
- 2
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.61