Association between serum 25-hydroxyvitamin D concentration and the risk of colorectal cancer: A cross-sectional study
Our findings indicate a strong inverse association between serum 25(OH)D concentrations and the risk of CRC, particularly when levels are ≤75 nmol/L. Maintaining serum 25(OH)D above 75 nmol/L is associated with a lower CRC risk and may serve as a cost-effective preventive strategy. Public health measures, including routine vitamin D screening in high-risk populations and targeted supplementation, could further support CRC prevention efforts.
Authors
- Shujuan Fu
- Yu-Ru Wang
- Zhangjie Zhou
- Cunya Li
- Jian Chen (ORCID: https://orcid.org/0000-0003-0961-7317)
- Miaomiao Wang (ORCID: https://orcid.org/0000-0002-5280-4022)
- Yun Li (ORCID: https://orcid.org/0000-0003-0949-6519)
- Zhiying Wang (ORCID: https://orcid.org/0000-0002-7226-1686)
- Yi Zhong (ORCID: https://orcid.org/0000-0001-5320-0725)
- Tingting Wu (ORCID: https://orcid.org/0000-0002-6229-7319)
- Siqi Feng (ORCID: https://orcid.org/0000-0002-7535-2364)
- Zhixian Zhong
- Wu Peng
Institutions
- Shanghai University (CN)
- Tongji University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Community Health Center (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1371/journal.pone.0320335
- Citations
- 1
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47