METTL3-mediated m6A modification of circSTAT6 modulates miR-188-3p/Beclin1 axis to promote osteogenic differentiation of mesenchymal stem cells
The present study revealed, for the first time, that METTL3-mediated m6A modification of circSTAT6 regulated the miR-188-3p/Beclin1 axis to promote the osteogenic differentiation of BMSC. These findings offer a potential therapeutic target for the treatment of OP.
Authors
- Yubo Shi (ORCID: https://orcid.org/0000-0002-5664-7511)
- Hui Cao (ORCID: https://orcid.org/0000-0003-2821-605X)
- Yue Luo (ORCID: https://orcid.org/0000-0002-9934-5839)
- Yanqing Wu (ORCID: https://orcid.org/0000-0003-3342-5999)
Institutions
- Hubei University of Medicine (CN)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13018-025-05720-4
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Natural Science Foundation of Hubei Province