Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol
While conventional radiosensitizers primarily target DNA and its repair mechanisms, our study introduces a strategy to enhance radiotherapy by specifically activating ferroptosis within the irradiated area, thereby minimizing systemic toxicity. Such a strategy of controlled activation of ferroptosis offers a favorable therapeutic index and potentially opens avenues for clinical application.
Authors
- Xinrui Ma (ORCID: https://orcid.org/0000-0002-7970-3387)
- Fangchao Jiang (ORCID: https://orcid.org/0000-0002-3679-4012)
- Yu‐Fei Wu (ORCID: https://orcid.org/0000-0002-3970-3999)
- Jin Xie (ORCID: https://orcid.org/0000-0002-8915-6233)
- Pakteema Tong
- Zhengwei Cao
- Libin Xu (ORCID: https://orcid.org/0000-0003-1021-5200)
- Wei Yang (ORCID: https://orcid.org/0000-0001-6905-2296)
- Ian Delahunty
- Shuyue Zhan (ORCID: https://orcid.org/0000-0003-2602-4484)
- Yong Teng (ORCID: https://orcid.org/0000-0002-1856-7289)
- Zhi Liu (ORCID: https://orcid.org/0000-0001-9785-9150)
- Jiayi Wang (ORCID: https://orcid.org/0009-0007-4011-6955)
- Jianwen Li (ORCID: https://orcid.org/0000-0002-3936-937X)
- Zibo Li (ORCID: https://orcid.org/0000-0001-8065-7923)
- Amy Li (ORCID: https://orcid.org/0000-0002-7732-3540)
- Fanghui Chen (ORCID: https://orcid.org/0009-0007-5382-4352)
- He Zhang (ORCID: https://orcid.org/0009-0001-1899-2402)
Institutions
- University of North Carolina at Chapel Hill (US)
- Emory University (US)
- University of Georgia (US)
- University of Washington (US)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12951-025-03303-3
- Citations
- 6
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- Winship Cancer Institute
- National Cancer Institute
- National Institute of Environmental Health Sciences
- Congressionally Directed Medical Research Programs