LRPPRC confers enhanced oxidative phosphorylation metabolism in triple-negative breast cancer and represents a therapeutic target
This work demonstrated a new regulatory pathway of TNBC to promote the expression of mitochondrial genes by upregulating the nuclear gene LRPPRC, resulting in increased OXPHOS. We also suggested a promising therapeutic target LRPPRC for TNBC, and its inhibitor, the traditional gynecological medicine GAA, presented significant antitumor activity.
Authors
- Dachi Wang (ORCID: https://orcid.org/0009-0008-7535-8564)
- Q. K. Xue (ORCID: https://orcid.org/0000-0002-2789-3545)
- Xiangsheng Liu (ORCID: https://orcid.org/0000-0002-5719-2838)
- Xiaohong Fang (ORCID: https://orcid.org/0000-0002-2018-0542)
- Tianyu Zhang (ORCID: https://orcid.org/0000-0002-3384-3288)
- Wenxi Wang (ORCID: https://orcid.org/0000-0002-9060-0901)
- Xiying Shao (ORCID: https://orcid.org/0000-0003-3547-3628)
- Wei Zhou (ORCID: https://orcid.org/0009-0001-1577-0820)
- Tingting Shen (ORCID: https://orcid.org/0000-0002-8446-9978)
- Xiaojia Wang
- Jie Liu
Institutions
- Chinese Academy of Sciences (CN)
- Institute of Computing Technology (CN)
- Zhejiang Cancer Hospital (CN)
- Hangzhou Academy of Agricultural Sciences (CN)
- Institute of Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s12967-024-05946-6
- Citations
- 11
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Natural Science Foundation of China