Colorectal cancer cells-derived exosomal miR-188-3p promotes liver metastasis by creating a pre-metastatic niche via activation of hepatic stellate cells
Exosomal miR-188-3p derived from CRC cells can promote liver metastasis by activating HSCs to form a PMN through targeting PHLPP2 to activate the AKT/mTOR pathway. These results offer a new perspective on the mechanisms driving CRLM.
Authors
- Yang Liu (ORCID: https://orcid.org/0000-0002-7137-9287)
- Yao Yao (ORCID: https://orcid.org/0009-0006-3344-1947)
- Tao Li (ORCID: https://orcid.org/0000-0003-0104-3494)
- Xiong Lei (ORCID: https://orcid.org/0000-0002-4055-3414)
- Taiyuan Li (ORCID: https://orcid.org/0000-0002-1747-1744)
- Yahang Liang
- Yuli Yuan
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s12967-025-06334-4
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- National Natural Science Foundation of China