β2-microglobulin and cognitive decline: unraveling the mediating role of the Dunedin Pace of Aging methylation
These findings suggested a substantial link between elevated B2M levels and cognitive decline among U.S. older adults, partly mediated through the faster pace of aging. This correlation highlights the potential of B2M as a biomarker for early detection and therapeutic intervention of aging-related cognitive decline.
Authors
- Min Liang (ORCID: https://orcid.org/0000-0002-6313-2022)
- Chengbiao Wu (ORCID: https://orcid.org/0000-0002-3660-088X)
- Kai Zeng (ORCID: https://orcid.org/0000-0002-5851-3162)
- Qinqin Wang (ORCID: https://orcid.org/0000-0002-3328-704X)
- Ping Chen (ORCID: https://orcid.org/0000-0002-9940-4528)
- Yujun Ke (ORCID: https://orcid.org/0009-0000-1838-7221)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fnagi.2025.1505185
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61