The catabolic nature of fermentative substrates influences proteomic rewiring in Escherichia coli under anoxic growth

Thus, the nature of catabolic substrates imposed either uptake limitation or metabolic limitation coupled with ribosomal limitation (arising due to anoxic and nutritional stress), which resulted in higher proteome expenditure leading to sub-optimal growth phenotype. This study can form the basis for analyzing E. coli's ability to optimize metabolic efficiency under different environmental conditions- including stress responses. It can be further extended to optimizing the industrial anaerobic conversions for improving productivity and yield.