Peptide hydrogel platform encapsulating manganese ions and high-density lipoprotein nanoparticle-mimicking nanovaccines for the prevention and treatment of gastric cancer
This study presents a novel strategy for clinical anti-tumor vaccine administration, offering a promising approach for the prevention and treatment of gastric cancer. The single-injection peptide hydrogel-based nanovaccine system provides a convenient and effective method to enhance the body's immune response against gastric cancer. This approach could potentially be expanded to other types of cancer, providing a versatile platform for cancer immunotherapy.
Authors
- Xu Huang (ORCID: https://orcid.org/0000-0001-7091-5773)
- Yufan Lv
- Ke‐Jun Li (ORCID: https://orcid.org/0000-0002-7255-9044)
- Zengxing Zhang (ORCID: https://orcid.org/0000-0001-7085-4077)
- Hong Lin (ORCID: https://orcid.org/0000-0001-6267-798X)
- Lei Shen (ORCID: https://orcid.org/0000-0002-2681-9300)
- Junjian Deng (ORCID: https://orcid.org/0000-0002-8632-6495)
Institutions
- Wuhan University (CN)
- Qihe People's Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s12967-025-06088-z
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64