Discovery of a DNA repair-associated radiosensitivity index for predicting radiotherapy efficacy in breast cancer
In conclusion, we established a radiosensitivity model for predicting radiotherapy benefit in breast cancer. Our study reveals a strong association between radiosensitivity, enhanced antitumor immunity, and potential immunotherapy benefit, particularly within the RS-PD-L1-high subgroup.
Authors
- Tianwen Xu (ORCID: https://orcid.org/0000-0003-2519-8140)
- Jianguang Lin (ORCID: https://orcid.org/0000-0003-3480-8676)
- Hainan Yang (ORCID: https://orcid.org/0000-0001-6864-1478)
- Rongfu Huang
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fonc.2025.1439516
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05