Exploring lipid-modifying therapies for sepsis through the modulation of circulating inflammatory cytokines: a Mendelian randomization study
This study supports a causal effect of genetically proxied CETP inhibitors in reducing the risk of sepsis-related critical care admission and death. These findings suggest that the underlying mechanism may involve the modulation of some circulating inflammatory cytokines, influencing the inflammatory response pathway.
Authors
- Chuanzhu Lyu
- Jinfang Xue (ORCID: https://orcid.org/0009-0003-8281-9481)
- Quan Li (ORCID: https://orcid.org/0000-0001-7536-5475)
- Yun Qu (ORCID: https://orcid.org/0000-0002-1197-4164)
- Hai Kang
Institutions
- University of Electronic Science and Technology of China (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- World Journal of Emergency Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5847/wjem.j.1920-8642.2025.045
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00