Characterizing the immune infiltrate in secondary syphilis: implications for transmission and pathology
Our data provide novel insights into the contribution of epidermal TLR sensing through MYD88 to the host response to syphilis infection, highlighting mechanisms by which <i>T. pallidum</i> evades immune responses in skin that may facilitate transmission of this pathogen through the skin.
Authors
- Craig J. Dobry (ORCID: https://orcid.org/0000-0002-1468-1156)
- Linda H. Xu (ORCID: https://orcid.org/0000-0002-9351-4822)
- Lorenzo Giacani (ORCID: https://orcid.org/0000-0003-3889-7274)
- Mrinal K. Sarkar (ORCID: https://orcid.org/0000-0001-8505-4259)
- Joseph Kirma (ORCID: https://orcid.org/0000-0002-2890-6897)
- Paul W. Harms (ORCID: https://orcid.org/0000-0002-0802-2883)
- Irène Gallais Sérézal (ORCID: https://orcid.org/0000-0002-7301-9699)
- Lam C. Tsoi (ORCID: https://orcid.org/0000-0003-1627-5722)
- Johann Eli Gudjonsson (ORCID: https://orcid.org/0000-0002-0080-0812)
- Joanne Michelle Kahlenberg (ORCID: https://orcid.org/0000-0002-4006-8945)
- Xianying Xing (ORCID: https://orcid.org/0000-0003-4227-6868)
- Jennifer Fox
- Anthony Coon
- Allison C. Billi (ORCID: https://orcid.org/0000-0001-7115-9113)
- C. Cole (ORCID: https://orcid.org/0000-0002-5747-4018)
- Rachael Bogle (ORCID: https://orcid.org/0000-0003-3544-3023)
- Kelsey R. vanStraalen
Institutions
- Inserm (FR)
- University of Washington (US)
- University of Michigan (US)
- Erasmus MC (NL)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1549206
- Citations
- 1
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16