Neuronal Degeneration and Glial Activation in the Absence of Vascular Changes in Human Retinas of Patients With Diabetes
The degeneration of neurons and synaptic connectivity within the macula in individuals with DM, even in the absence of clinical vascular signs, is associated with impaired visual function. These early changes suggest potential new biomarkers for imaging techniques and emphasize the need for therapies for diabetic patients without clinical signs.
Authors
- Nicolás Cuenca (ORCID: https://orcid.org/0000-0002-6767-5710)
- Natalia Martínez‐Gil (ORCID: https://orcid.org/0000-0001-8882-5602)
- Xavier Sánchez‐Sáez (ORCID: https://orcid.org/0000-0001-5128-0979)
- Henar Albertos‐Arranz (ORCID: https://orcid.org/0000-0001-8656-9887)
- Pedro Lax (ORCID: https://orcid.org/0000-0001-6931-1008)
- Julio Cesar Molina-Martín
Institutions
- University of Alicante (ES)
- Hospital Universitari Sant Joan D'Alacant (ES)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1167/iovs.66.3.53
- Citations
- 6
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.05