Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence
The findings suggest a sex-specific kynurenine pathway alteration in adolescent depression. Female adolescents at higher risk for or with depression showed a reduction in neuroprotective metabolites. An increased diversion of kynurenine toward production of neurotoxic metabolites predicted persistent depression in female adolescents with MDD.
Authors
- Helen L. Fisher (ORCID: https://orcid.org/0000-0003-4174-2126)
- Laila Souza (ORCID: https://orcid.org/0009-0002-7203-6064)
- Pedro H. Manfro (ORCID: https://orcid.org/0000-0003-0950-6844)
- Jader Piccin (ORCID: https://orcid.org/0000-0003-4191-6966)
- Jin Xu (ORCID: https://orcid.org/0000-0003-3072-1899)
- Cristina Legido‐Quigley (ORCID: https://orcid.org/0000-0002-4018-214X)
- Naghmeh Nikkheslat (ORCID: https://orcid.org/0000-0002-9427-6715)
- Rivka Pereira
- Christian Kieling (ORCID: https://orcid.org/0000-0001-7691-4149)
- Valeria Mondelli (ORCID: https://orcid.org/0000-0001-8690-6839)
- Brandon A. Kohrt (ORCID: https://orcid.org/0000-0002-3829-4820)
- Zuzanna Zajkowska (ORCID: https://orcid.org/0000-0002-5214-305X)
- Anna Viduani
- Fernanda Rohrsetzer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- King's College London (GB)
- George Washington University (US)
- South London and Maudsley NHS Foundation Trust (GB)
- Hospital de Clínicas de Porto Alegre (BR)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1016/j.biopsych.2024.11.020
- Citations
- 14
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.09
Funders
- Pfizer
- Biogen
- National Institute for Health and Care Research
- Department of Health and Social Care
- Royal Academy of Engineering
- King's College London
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Novo Nordisk
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Universidade Federal do Rio Grande do Sul
- Medical Research Council
- Economic and Social Research Council
- National Institute of Mental Health