<scp>FTO</scp> Promotes Osteogenic Differentiation of Human <scp>BMSCs</scp> via Demethylation of <scp> TGFB2 m <sup>6</sup> A </scp> Modifications
These results indicate that upregulated m<sup>6</sup>A eraser FTO downregulates m<sup>6</sup>A modifications promoting TGFB2 expression in hBMSCs that trigger osteogenic differentiation, suggesting activation of FTO or TGFB2 as a strategy to promote hBMSC-based bone defect repair.
Authors
- Yuzhuo Hei
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Antong Wu
- Mingjing Zhu (ORCID: https://orcid.org/0000-0002-7930-014X)
- Wenchao Zhong (ORCID: https://orcid.org/0000-0002-9864-225X)
- Rui Li (ORCID: https://orcid.org/0000-0002-9285-3005)
- Wanyi Chen (ORCID: https://orcid.org/0009-0000-8150-2624)
- Xingyang Li (ORCID: https://orcid.org/0000-0001-5265-1671)
- Lan Tan (ORCID: https://orcid.org/0000-0002-8759-7588)
- KaiTong Deng
- Ziyi Zhang (ORCID: https://orcid.org/0000-0002-2175-4931)
- Xin Li (ORCID: https://orcid.org/0000-0002-5175-5409)
- Qingbin Zhang (ORCID: https://orcid.org/0000-0002-8523-9293)
- Wenyi Cai
- Siqing Jiang (ORCID: https://orcid.org/0000-0002-0699-9201)
- Wei Cao (ORCID: https://orcid.org/0000-0001-7573-5106)
Institutions
- Shenzhen University (CN)
- Academic Center for Dentistry Amsterdam (NL)
- Fourth People’s Hospital of Jinan (CN)
- Stomatology Hospital (CN)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Oral Diseases
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1111/odi.15324
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province