Thinner Induced Multiple Organ Toxicities in Wistar Rats: Ameliorative Role of Vitamin E (Alpha-Tocopherol)

Thinner, a common industrial solvent, is a popular choice for recreational self-intoxication, leading to potential serious health consequences. This study delves into the acute toxicity of thinner, focusing on its impact on various organ systems and the potential ameliorative ability of Vitamin E as an antioxidant. Four experimental groups of Wistar rats (n-12) were established as follow: control, Vitamin E only, thinner only and thinner + Vitamin E. The rats were subjected to a 3week inhalation protocol, and various parameters such as body weight, biochemical markers (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TBIL), blood urea nitrogen (BUN) and creatinine levels), oxidative stress markers (malondialdehyde, nitrites, glutathione, catalase and superoxide dismutase), and histopathological examinations were assessed using standard procedures. The results revealed a significant reduction in body weight in the thinner-exposed group. However, the group exposed to both thinner and Vitamin E exhibited marked increase in body weight. Biochemical parameters (AST, ALT, ALP, TBIL, BUN and creatinine) were significantly elevated (p