Clear-Cell Renal Cell Carcinoma Molecular Subtypes Differ by African and European Genetic Similarity
Our study shows that AFR genetic similarity correlates with distinct ccRCC molecular subtypes. Further research is needed to disentangle environmental and genetic influences. Identifying these differences underscores the critical importance of including racially and ethnically diverse populations in cancer research to ensure more equitable and sustainable outcomes worldwide for all patients.
Authors
- David McKean (ORCID: https://orcid.org/0000-0002-7272-4409)
- Sunil Patel (ORCID: https://orcid.org/0000-0002-5045-0152)
- Shirley Wang (ORCID: https://orcid.org/0000-0003-3564-4415)
- Ridwan Alam (ORCID: https://orcid.org/0000-0001-7805-9596)
- Mohamad E. Allaf (ORCID: https://orcid.org/0000-0003-3333-3904)
- Elana J. Fertig (ORCID: https://orcid.org/0000-0003-3204-342X)
- Alison Patricia Klein (ORCID: https://orcid.org/0000-0003-2737-8399)
- Michael E. Rezaee (ORCID: https://orcid.org/0000-0002-6236-8682)
- Nirmish Singla (ORCID: https://orcid.org/0000-0001-9495-6983)
- Anirudh Yerrapragada (ORCID: https://orcid.org/0000-0002-4150-6548)
- Joseph Cheaib (ORCID: https://orcid.org/0000-0003-1679-2682)
- Thomas R. Nirschl (ORCID: https://orcid.org/0000-0002-3329-6229)
- Yasser Ged (ORCID: https://orcid.org/0000-0001-6671-7002)
- Ezra Baraban (ORCID: https://orcid.org/0000-0001-6932-8985)
- Srinivasan Yegnasubramanian (ORCID: https://orcid.org/0000-0003-0744-6606)
- Roy Elias (ORCID: https://orcid.org/0000-0002-8555-4322)
- Yuezhou Jing (ORCID: https://orcid.org/0000-0002-4597-7064)
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Baltimore (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0624
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52