Effects of neoadjuvant and adjuvant chemotherapy on survival in muscle-invasive bladder cancer: A multicenter study
Aim: Muscle-invasive bladder cancer requires systemic treatment due to its high risk of metastasis. However, studies comparing neoadjuvant and adjuvant therapy regimens are currently limited. Our goal in this study was to compare the treatment efficacy of patients receiving neoadjuvant or adjuvant treatment in locally advanced bladder cancer. Material and Methods: We retrospectively included 107 bladder cancer patients from 6 centres who underwent radical cystectomy and received perioperative chemotherapy. Patients were divided into 2 categories: (i) neoadjuvant chemotherapy (n=54) and (ii) adjuvant chemotherapy (n=53). Results: Median follow-up was 31.6 months (95%CI 21.8-41.4). 30-month disease-free survival (DFS) was 58.9% in the whole group, 56.3% in neoadjuvant and 61.5% in adjuvant. 30-month DFS after neoadjuvant treatment was 70.1% in
Authors
- İbrahim Vedat Bayoğlu (ORCID: https://orcid.org/0000-0002-0481-1084)
- Selver Işık (ORCID: https://orcid.org/0000-0002-2726-1740)
- Osman Köstek (ORCID: https://orcid.org/0000-0002-1901-5603)
- Nargız Majidova (ORCID: https://orcid.org/0000-0002-2575-5819)
- Pınar Erel (ORCID: https://orcid.org/0000-0002-2797-2075)
- Rukiye Arıkan (ORCID: https://orcid.org/0000-0003-2688-1515)
- Sevdenur Taşkın (ORCID: https://orcid.org/0000-0002-3674-244X)
- Ali Kaan Güren (ORCID: https://orcid.org/0000-0002-3562-5006)
- Abdüssamet Çelebi (ORCID: https://orcid.org/0000-0002-6922-1018)
- S. Seber (ORCID: https://orcid.org/0000-0001-9081-2405)
- Murat Sarı (ORCID: https://orcid.org/0000-0003-0596-1559)
- Murat Arcagök (ORCID: https://orcid.org/0000-0002-4058-6929)
- Rumeysa Çolak (ORCID: https://orcid.org/0000-0002-3867-0793)
- Zuhat Urakçı (ORCID: https://orcid.org/0000-0003-3878-988X)
- Yeşim Ağyol (ORCID: https://orcid.org/0000-0002-4409-6003)
- Erkam Kocaaslan (ORCID: https://orcid.org/0000-0002-8994-2904)
- Özge Yalıcı (ORCID: https://orcid.org/0009-0002-0260-7511)
- Ahmet Emin Öztürk (ORCID: https://orcid.org/0000-0003-3365-5540)
- Yaprak Ḉaḡlar
- Mehmet Cihan İcli̇ (ORCID: https://orcid.org/0000-0002-7857-6902)
- Nadiye Sever
- Barış Köksal (ORCID: https://orcid.org/0000-0002-0418-5749)
Institutions
- Dicle University (TR)
- Tekirdağ Namık Kemal University (TR)
- Bakırköy Psychiatric Hospital (TR)
- University of Health Sciences (SO)
- Hacettepe University (TR)
- Marmara University (TR)
Publication Details
- Journal
- Turkish Journal of Clinics and Laboratory
- Published
- 2025-03-25
- DOI
- https://doi.org/10.18663/tjcl.1575691
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00