THE USE OF INFORMATION SYSTEMS TO ASSESS THE DYNAMICS OF ANTIBODY REGRESSION IN CHILDREN WITH PERINATAL CONTACT BORN TO HIV-INFECTED MOTHERS

The determination of antibodies to the antigenic structures of the HIV-1 and HIV-2 genotypes in children with perinatal contact makes it possible to determine their dynamics using the functionality of the laboratory information system, as well as to make decisions on de-registration at the end of the follow-up period. The data obtained on differentiated antibodies to individual proteins by enzyme immunoassay in laboratory conditions are analyzed. Since all children of HIV-positive mothers also have maternal antibodies during the examination, which regress from the blood of a healthy child by an average of 1.5 years, in accordance with Clinical Recommendations, as part of the ongoing follow-up, children are examined for antibodies, which (in addition to negative polymerase chain reaction studies and lack of breastfeeding) are one of the criteria withdrawal from follow–up (category with diagnosis R75 - children with an inconclusive laboratory result for HIV infection). The use of this analysis and its assessment in dynamics will improve measures in terms of follow-up, pregnancy planning and reduction of perinatal HIV transmission, including taking into account the decision on timely three-stage chemoprophylaxis in mother-child pairs.