Investigation of Anti-CA II Antibodies in The Sera of Helicobacter Pylori Infected Patients

It has been postulated that there may be a correlation between gastric infection caused by Helicobacter pylori (H. Pylori) and autoimmune pancreatitis (AIP). An increase in carbonic anhydrase II (CA II) autoantibodies was found in the sera of patients with AIP and it was suggested that measurement of these autoantibodies could be used in the diagnosis of AIP. In this study, the levels of CA II autoantibodies have been determined in the sera of the patients with H. pylori-infected gastritis and gastric ulcer. Anti-CA II antibody levels in the sera of these individuals were measured by ELISA method. There were significant differences between the control group and the H. pylori-infected gastric ulcer group and the gastritis group. When the H. pylori-infected and non-infected gastric ulcer and gastritis groups were compared, it became apparent that there were notable differences. The results indicated that the CA II antibodies in the sera of the H. pylori-infected patients were present at a rate of 8.3%. This led to the conclusion that CA II antibodies may not be a reliable marker for H. pylori infection. However, the investigation did demonstrate a clear increase in the levels of CA II antibodies for H. pylori-infected patients.