Outside Back Cover: DNA Framework‐Ensembled Aptamers Enhance Fluid Stability in Circulating Tumor Cells Capture for Tumor Treatment Evaluation (Angew. Chem. Int. Ed. 15/2025)
Framework nucleic acids (FNAs), as precisely engineered structural nucleic acids, enable precise regulation of molecular recognition between receptors and ligands. In their Research Article (e202425252), Xiaolei Zuo and co-workers developed a tetrahedral DNA framework-engineered multivalent aptamer system (TEAn) for the highly efficient capture of circulating tumor cells (CTCs) and accurate monitoring of clinical treatment progression.
Authors
- Chunhai Fan (ORCID: https://orcid.org/0000-0002-7171-7338)
- Yi‐Rong Chen (ORCID: https://orcid.org/0000-0002-4307-3002)
- Chenzhou Mao (ORCID: https://orcid.org/0009-0000-7579-9900)
- Shuyang Zhang (ORCID: https://orcid.org/0009-0009-9758-5861)
- Xiaolei Zuo (ORCID: https://orcid.org/0000-0001-7505-2727)
- Jinhua Jiang (ORCID: https://orcid.org/0000-0003-2779-6865)
- Feng Liu (ORCID: https://orcid.org/0000-0002-2082-7561)
- Fan Li (ORCID: https://orcid.org/0000-0001-8582-4911)
- Min Li (ORCID: https://orcid.org/0000-0003-2606-5315)
- Yueyue Zhang
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1002/anie.202506102
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00