COMENIC ACID: POSSIBILITIES AND PROSPECTS

Human existence in the conditions of modern technogenic civilization, negative influence of environmental factors: tobacco smoke, polluted air, radiation and ultraviolet radiation, drugs, anesthetics, pesticides, industrial solvents, as well as excessive physical activity, overwork, accumulation of stressful situations are accompanied by an increase in the formation of free radicals in the body and leads to the development of diseases in various organs and systems [1] Metabolic and energy disorders, accumulation of active damaging agents that lead to disruption of cell functioning and their death, as well as leading to the development of various pathological conditions, is called oxidative stress[2] It is known that oxidative stress, or uncontrolled increase in free radical reactions, is an important pathogenetic factor in the development of diseases of the heart, bronchopulmonary system, oncological, rheumatic, neurodegenerative processes. [3] Therefore, it is very important to find a drug that will affect this link in pathogenesis. One of the promising antioxidants with a multimodal mechanism of action is comenic acid, its salts and complex compounds. The purpose of the scientific article was to review the literature on the use of comenic acid in medicine, due to its antioxidant, sedative, neurotropic, anti-withdrawal, anxiolytic and regenerative properties. Materials and methods are a review of Russian and foreign sources on the topics: the effect of oxidative stress and free radicals on the pathogenesis of diseases, as well as the use and application of comenic acid, its salts and complex compounds in medicine. The protective role of comenic acid in glutamate neurotoxicity accompanied by oxidative stress, as well as in non-narcotic analgesic activity, has been proven, which makes the use of this substance in the medical field very popular. But for this, research and experiments on animals, followed by a transition to double-blind randomized studies on humans, still need to be carried out, so that the drug can enter practical medical use.