Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures
This study elucidated the causal relationships between antibody immune responses, immune cells, and osteoporosis or fractures. The HLA gene family plays a crucial role in the interaction between antibodies and these bone conditions, with HLA-DPB1 identified as a key risk gene. Immune cells do not serve as mediators in this process. These findings provide valuable insights for future research.
Authors
- Yingying Qin
- Jichong Zhu (ORCID: https://orcid.org/0000-0003-3701-5620)
- Chong Liu (ORCID: https://orcid.org/0000-0003-2479-3001)
- Guiyu Li (ORCID: https://orcid.org/0000-0003-3898-2436)
- Jiarui Chen (ORCID: https://orcid.org/0000-0001-8197-4592)
- Keli Ou
- Weiming Tan
- Cheng Wei
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
- Affiliated Hospital of Guilin Medical College (CN)
- Nanxi Mountain Hospital (CN)
Publication Details
- Journal
- Clinics in Orthopedic Surgery
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4055/cios24445
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42