Synthesis of some novel coumarin-pyrimidine hybrid compounds from 8- and 6-acetyl-7-hydroxy-4-methylcoumarin

Coumarins are heterocyclic compounds which can exhibit a wide range of significant biological and pharmacological properties.Coumarin-pyrimidine hybrids integrate structural elements of both coumarin and pyrimidine, often exhibiting enhanced biological activities due to the synergistic interaction of the two pharmacophores.Starting from 6-and 8-acetyl-7-hydroxy-4-methylcoumarin, a total of twenty-one novel compounds, identified as 8-and 6-(2-amino-6-arylpyrimidin-4-yl)-7-hydroxy-4-methylcoumarins, were successfully synthesized.The synthesized pyrimidines demonstrated significant antimicrobial activity, effectively inhibiting Klebsiella pneumoniae, Staphylococcus epidermidis, and, more prominently, Candida albicans, with aseptic zone diameters reaching up to 30 mm at concentrations of 150 g/ l.