Alginate-hydroxyapatite scaffolds: A comprehensive characterization study

The findings emphasize the potential of Alg-HA scaffolds for dentin regeneration. Their porous architecture, combined with embedded HA, enhances mechanical stability while providing essential biochemical cues for cell proliferation and mineralization. The demonstrated hemocompatibility ensures safe application in direct blood contact, reducing immune responses and promoting tissue integration. Compared to previous studies, this research offers a more in-depth understanding of the relationship between porosity, mineralization, and cellular behavior. Alginate-hydroxyapatite scaffolds exhibit excellent structural, chemical, and biological properties, making them promising candidates for regenerative dentistry. With excellent degradation, hemocompatibility, and ability to support cellular functions, these scaffolds hold significant potential for clinical applications, with further optimization paving the way for broader medical adoption.