Disease pathogenicity in Hutchinson–Gilford progeria syndrome mice: insights from lung-associated alterations
This study unveiled the previously overlooked organs involved in HGPS pathogenesis and suggested a specific emphasis on the lung. Our findings suggest that pulmonary abnormalities may contribute to disease progression, warranting further investigation into their role in HGPS monitoring and management.
Authors
- Langping Gao
- Lidan Hu (ORCID: https://orcid.org/0000-0002-1145-2745)
- Fangqin Wang
- Jingjing Wang (ORCID: https://orcid.org/0000-0003-0840-8310)
- Jenny I. Shen (ORCID: https://orcid.org/0000-0002-2993-403X)
- Yuhan Ding (ORCID: https://orcid.org/0000-0001-9263-7364)
- Xudong Fu (ORCID: https://orcid.org/0000-0001-7024-0200)
- Yue Wang (ORCID: https://orcid.org/0000-0002-0278-2347)
- Xiangjun Chen
- Junyi Tan (ORCID: https://orcid.org/0009-0003-9290-6685)
- Haidong Fu (ORCID: https://orcid.org/0000-0001-9459-3078)
- Jianhua Mao (ORCID: https://orcid.org/0000-0002-6076-3806)
- Yuelin Guan
- J. Lin
- Zhongkai Cao
Institutions
- Children's Hospital of Zhejiang University (CN)
- Hubei Normal University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s10020-025-01165-x
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China