Palladium-Catalyzed Cascade Carbonylation Reaction To Construct Ester Derivatives
We have developed a palladium-catalyzed ester carbonylation reaction that enables the synthesis of ester-substituted benzofuran derivatives in a single step through the introduction of alkyl halides undergoing in situ hydrolysis and alkynyl aryl iodides. This method demonstrates broad applicability to both primary and secondary alkyl halides while maintaining excellent functional group compatibility under low palladium loading conditions. Notably, this strategy significantly expands the scope of the ester carbonylation reactions.
Authors
- Dong‐Yu Miao
- Xi‐Cun Wang (ORCID: https://orcid.org/0000-0003-3770-9817)
- Shun‐Xi Li
- Yi‐Feng Qiu (ORCID: https://orcid.org/0000-0002-2747-9598)
- Dong‐Ping Chen (ORCID: https://orcid.org/0009-0004-5314-7740)
- Fei Yang (ORCID: https://orcid.org/0000-0001-7390-7111)
- Ming Li (ORCID: https://orcid.org/0000-0002-2207-0873)
- Zheng‐Jun Quan (ORCID: https://orcid.org/0000-0002-4393-3594)
- Shan-Mei Xu
- Yong‐Min Liang (ORCID: https://orcid.org/0000-0001-8280-8211)
Institutions
- State Key Laboratory of Applied Organic Chemistry
- Northwest Normal University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1021/acs.joc.4c03169
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81