Image-Guided Stereotactic Body Radiotherapy (SBRT) with Enhanced Visualization of Tumor and Hepatic Parenchyma in Patients with Primary and Metastatic Liver Malignancies
SPION Ferumoxytol<sup>®</sup> administered intravenously as an alternative MRI contrast agent on the day of SBRT planning produces a long-lasting contrast effect between tumors and functional hepatic parenchyma for precision targeting and guided avoidance during the entire course of liver SBRT, enabling fast and accurate online plan adaptation on the 1.5 T Elekta Unity MR-Linac. This approach demonstrates a safe and effective bridging therapy for patients with hepatic cirrhosis, leading to low toxicity and favorable transplant outcomes.
Authors
- Mark Bunker
- Parisa Shamsesfandabadi (ORCID: https://orcid.org/0000-0002-9428-9225)
- Ángela Sanguino
- Chirag Shah (ORCID: https://orcid.org/0000-0002-9295-5554)
- Alexander Kirichenko (ORCID: https://orcid.org/0000-0002-6457-1190)
- Patrick L. Wagner (ORCID: https://orcid.org/0009-0004-3935-5316)
- Tadahiro Uemura
- Seungjong Oh
- Allen M. Chen (ORCID: https://orcid.org/0000-0002-4582-712X)
- Danny Lee (ORCID: https://orcid.org/0000-0003-3270-1066)
- Hannah Lee (ORCID: https://orcid.org/0000-0002-1663-9170)
- Daniel Pavord
- Lorenzo Machado
Institutions
- Allegheny Health Network (US)
- Allegheny General Hospital (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3390/cancers17071088
- Citations
- 2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.64